Biomechanical Characterization of Fibroblast-Populated Collagen Tissue Models
نویسندگان
چکیده
منابع مشابه
A review of fibroblast-populated collagen lattices.
Bell's introduction of the fibroblast-populated collagen lattice (FPCL) has facilitated the study of collagen-cell interactions. As a result of the numerous modifications of the casting of FPCLs, the in vivo applications of these in vitro findings have been confusing. Here experimental FPCL contraction findings are viewed in regard to three proposed mechanisms responsible for lattice contractio...
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Remodeling of collagen fibrils is involved in a variety of physiological and pathological processes including development, tissue repair, and metastasis. Fibroblast-populated collagen gel contraction has been employed as a model system to investigate the collagen fibril remodeling within three-dimensional collagen matrices. Research on collagen gel contraction is also important for understandin...
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The defined, serum-free media used in the cultivation of skin equivalents are liable to inter-laboratory variations, require the preparation of multiple additives, and are potentially difficult to replicate. In this study, we assessed the use of standardized, serum-free and bovine pituitary extract-free keratinocyte culture media in the development of a human skin equivalent. After culture at t...
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THE HYALOCYTES ARE MORE NUMEROUS IN THE POSTERIOR CHAMBER THANTHEYARElNTHEVITREOUS,AND?HBYDONOTREACTWllHAN ANTIBODY TO RABBK MACROPHAGES. HADDAD A. and AND& J.C. _ Fat. Medicina de Ribeiti Preto, USP, Brazil. Purpm To dctermux the distribution and nahue of free cells inslde the eye chambers. Methods The cdl uwm were performed on IS n0n-mnsecutive par&n sech(yIs per eye (starned ~10th H.E.) of 1...
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BACKGROUND Dupuytren's disease (DD) is a debilitating fibro-proliferative disorder of the hand characterized by the appearance of fibrotic lesions (nodules and cords) leading to flexion contractures of the fingers and loss of hand function. Although the molecular mechanism of DD is unknown, it has been suggested that transforming growth factor-beta2 (TGF-beta2) may play an important role in the...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.2021